There are 5 ways to get from Chicago to St. Louis by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Chicago Midway  •  3 h 11 min

  1. Fly from Chicago Midway (MDW) to St. Louis (STL) MDW - STL

$125 - $307

Cheapest option

Bus  •  5 h 45 min

  1. Take the bus from Chicago, Il to St Louis, Mo 1353

$30 - $85

3 alternative options

Fly from Chicago O'Hare  •  3 h 26 min

  1. Fly from Chicago O'Hare (ORD) to St. Louis (STL) ORD - STL

$90 - $248

Train  •  5 h 30 min

  1. Take the train from Chicago Union Station Amtrak to St. Louis Gateway Station Amtrak Lincoln Service / ...

$50 - $130

Drive  •  4 h 53 min

  1. Drive from Chicago to St. Louis 297.4 miles

$29 - $45

Questions & Answers

The cheapest way to get from Chicago to St. Louis is to drive which costs $29 - $45 and takes 4 h 53 min.

More details

The quickest way to get from Chicago to St. Louis is to fly which costs $120 - $310 and takes 3 h 11 min.

More details

The distance between Chicago and St. Louis is 264 miles. The road distance is 297.4 miles.

Get driving directions

It takes approximately 3 h 11 min to get from Chicago to St. Louis, including transfers.

More details

Yes, there is a direct bus departing from Chicago, Il and arriving at St Louis, Mo. Services depart hourly, and operate every day. The journey takes approximately 5 h 45 min.

More details

Yes, there is a direct train departing from Chicago Union Station Amtrak station and arriving at St. Louis Gateway Station Amtrak station. Services depart every four hours, and operate every day. The journey takes approximately 5 h 30 min.

More details

What companies run services between Chicago, IL, USA and St. Louis, MO, USA?

Southwest Airlines flies from Chicago to St. Louis every 4 hours. Alternatively, Amtrak operates a train from Chicago to St. Louis every 4 hours. Tickets cost $50 - $130 and the journey takes 5 h 30 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to St. Louis
Ave. Duration
1 h 5 min
When
Every day
Estimated price
$160 - $550
United Airlines
Website
united.com
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1 h 21 min
When
Every day
Estimated price
$120 - $650
American Airlines
Website
aa.com
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1 h 6 min
When
Every day
Estimated price
$120 - $550
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Chicago Union Station Amtrak to St. Louis Gateway Station Amtrak
Ave. Duration
5 h 30 min
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to St Louis, Mo
Ave. Duration
5 h 45 min
Frequency
Hourly
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.